Office 2013 ODT The operating system is not presently configured to run this application

Question

hi!
We have RDS 2012 R2 setup up and running with session host, connection broker, rd gateway and rd web. AS office 2013 can be deployed using APP-V 5 SP2, we have created .appv pkg using ODT as mentioned in this
guide . It was working fine for 2 days and then suddenly we started to get error popup window saying
"The operating system is not presently configured to run this application" . We are receiving this error on Session host server(win 2k12 r2) which is App-V 5 sp2 client, when we try to open any office 2013 app.
And If check on App-v server which is also a publishing server. In event viewer i see this log entry.
Log Name:      Microsoft-AppV-Server-Publishing/Admin
Source:        Microsoft-AppV-Server-Publishing
Event ID:      215
Level:         Error
Description:
The request URL doesn't contain the query string for the client OS.
Event Xml:
<Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
  <System>
    <Provider Name="Microsoft-AppV-Server-Publishing" Guid="{825C7963-9E32-4E3B-B74A-DF2CC3B6822B}" />
    <Execution ProcessID="3092" ThreadID="5176" />
    <Channel>Microsoft-AppV-Server-Publishing/Admin</Channel>
 </Event>
SaM

Answer 1

We have the same issue. All other applications seem to work fine.
App-V 5.0 SP1 with hotfix package 2 installed on the App-V Management/Publishing server. We only use Windows Server 2012 RDS instead of R2. On the RDS servers, App-V 5.0 SP2 is installed. We use User Profile Disks and also used the ODT for Office
2013.
I our case it worked for a few hours. We didn't change anything (no updates of other things) other than having a few users try to login with different accounts to test the application. Reinstalling the client doesn't work and we also tried to removed
all AppVClientPackages and then clear the cache from locations like:
%LOCALAPPDATA%\Microsoft\AppV\Client\VFS
%APPDATA%\Microsoft\AppV\Client\VFS
C:\ProgramData\App-V
I'll post a solution if I find one.