Once again users can't send or receive

We have an Xserve running 10.3.9. I've tried running the database rebuild routine and for a little while the mail started going out and was being received but now nobody can do anything with mail. I'm somewhat of a novice with mail servers but I had this thing working just fine for the longest time. Not nothing is working. I'm wondering if I should just create a new mail database an start from scratch. Not sure if that would help.
Please help. Here's my postconf -n:
always_bcc =
command_directory = /usr/sbin
config_directory = /etc/postfix
daemon_directory = /usr/libexec/postfix
debugpeerlevel = 2
enableserveroptions = yes
inet_interfaces = all
luser_relay =
mail_owner = postfix
mailbox_transport = cyrus
mailq_path = /usr/bin/mailq
manpage_directory = /usr/share/man
mapsrbldomains =
messagesizelimit = 20971520
mydestination = $myhostname,localhost.$mydomain,saintmichaelschool.org,mail1.saintmichaelschool .org,192.168.181.2
mydomain_fallback = localhost
myhostname = mail.saintmichaelschool.org
mynetworks = 127.0.0.0/8
mynetworks_style = host
newaliases_path = /usr/bin/newaliases
queue_directory = /private/var/spool/postfix
readme_directory = /usr/share/doc/postfix
relayhost =
sample_directory = /usr/share/doc/postfix/examples
sendmail_path = /usr/sbin/sendmail
setgid_group = postdrop
smtpdclientrestrictions =
smtpdenforcetls = no
smtpdpw_server_securityoptions = login
smtpdrecipientrestrictions = permitsasl_authenticated,permit_mynetworks,reject_unauthdestination,permit
smtpdsasl_authenable = yes
smtpdtls_certfile = /etc/postfix/server.pem
smtpdtlsloglevel = 0
smtpduse_pwserver = yes
smtpdusetls = no
unknownlocal_recipient_rejectcode = 450
Not sure where to go from here. But I'd really like to avoid reinstalling the entire server.

I have gone through the steps of reconstructing the database using the following command:
sudo -u cyrus /usr/bin/cyrus/bin/reconstruct -i
After starting the server back up it seemed to be working fine. After a few hours, though, the server refused to allow the sending of mail from the clients, and it stoped allowing the users to pop there mail. This is using both Mail.app on the Macs and Outlook on the PCs. It was the case that only the Windows users were not able to send mail prior to the recontruction of the database.
Following that I tried the following after stopping the mail server:
$ su root
# mv /var/imap /var/imap.old
# mkdir /var/imap
# /usr/bin/cyrus/tools/mkimap
# chown -R cyrus:mail /var/imap
# sudo -u cyrus /usr/bin/cyrus/bin/reconstruct -i
restarted the server and it was still not working. So I stopped the server and tried the following:
cp imapd.conf.default imapd.conf
then,
$ su root
# mv /var/imap /var/imap.old
# mkdir /var/imap
# /usr/bin/cyrus/tools/mkimap
# chown -R cyrus:mail /var/imap
# sudo -u cyrus /usr/bin/cyrus/bin/reconstruct -i
thinking that maybe my impad.conf file had gotten corrupt somehow. I restared the mail server and everything seems to be working at the moment from the Macs. I have yet to test the PCs.

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