OnPremise: Sharepoint Hosted App gives 401 unauthorized error while accessing UserProfile Rest Service

Question

Hi All,
I have SharePoint hosted app deployed on On-Premise using(F5) which reads User Profile data consumes WCF(Hosted on same server) through REST API to insert data in to SQL DB(Different server).
SharePoint hosted app was working as expected and suddenly it started asking for credential and not login(any user) to the application landing page.
Checked SharePoint Logs, IIS Logs and Windows log but did not get any clue.
WCF is accessible, User Profile access is also happening but not sure what changes done on server or infra level which causing this issue.
I have an On-Premise Environment for SharePoint 2013. where we have created SharePoint hosted app which calls "http:///_api/SP.UserProfiles.PeopleManager/GetMyProperties" to get current user's data. but this gives me 401 unauthorized error.
Notes:
I had given read permission to user profile and full control to sitecollection in appmanifest. If I run this app on Office 365 developer site it works fine, but on premise environment it give 401 error.
On premise environment when I deploy this app 3 times it prompt for  credential and finally gives the following error
Error message after login 3 times:
{"error":{"code":"-2147024891, System.UnauthorizedAccessException","message":{"lang":"en-US","value":"Access
denied. You do not have permission to perform this action or access this resource."}}}
-Lovekush Kumar 

Answer 1

Add your site (http://*.app.contoso.com) to your local intranet sites in IE. 
"app.contoso.com" is app domain.
My Blog- http://www.sharepoint-journey.com|
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