Open 5 error.  Is my hard drive toast?

My Mac Mini 1.66 Intel locked up last night. I had to use the power button toshut it down. Now I get a greay screen and the Apple logo when I try to boot. I booted from my external drive and was able to pull some of my files from the internal drive, but it locked up again as I was moving music. I tried to repair permission with disk utility on the internal drive while booted from the external. I could select the internal but none of the commands would execute. I then booted to the Loepard install disk, but had the same problem.
Today I booted from the external drive and got a message that the internal drive had an error. I had an option to repair permissions, but got the following:
Verifying volume “OSX”
The disk “OSX” could not be unmounted
Verify permissions for “OSX”
Reading permissions database.
Reading the permissions database can take several minutes.
Open error 5: "Input/output error" on System/Library/LaunchDaemons/com.apple.ATSServer.plist
Open error 5: "Input/output error" on System/Library/LaunchDaemons/com.apple.distnoted.plist
Open error 5: "Input/output error" on System/Library/LaunchDaemons/com.apple.CoreRAID.plist
Open error 5: "Input/output error" on System/Library/LaunchDaemons/com.apple.coreservicesd.plist
These same errors continued for a number of pages and finally ended with
Permissions verification complete

Hi Megan,
I have the same kind of issue as you have on my iMac24" late 2006.
My system was not starting anymore and after few checks and other unimportant reasons, I decided to erase install.
Here is what I did:
1. erased the hdd with option Zero Out data. no issue or error messages given
2. reinstalled the os x 10.5 from scratch. system was working fine until step 3.
3. i performed a SW update (combo update 10.5.6).
4. restarted on the forbidden sign road !
5. checked permissions with disc utility. get the same kind errors you had:
'Open error 5: "Input/output error" on System/Library/...'
6. perfomed extended apple HW test. no issue found.
I am on my way to erase and install again and to test without the OS X 10.5.6 combo update.
The problem is that I do not really know if the issue is software or hardware at that point.
Any ideas what I did wrong or what I should try.
I'll be glad if anyone could help me as I feel a bit like an idiot here
cheers
Florent

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