Open Error 6: Device not configured

I recently had my hard drive replaced and restored to factory settings. I then used a time machine backup and the Migration Assistant to get everything I had back to where it belonged.
Things worked for a day or so, but with a few crashes here and there. Yesterday, I tried to use iTunes and kept getting an error message about the database (-50, unable to mount database). The problem is that the whole system would freeze and I had to shut down and restart every time. Sometimes I could load the OS, sometimes not. This morning I ran Disk Utility to verify the disk (it passed) and the permissions. When I tried to repair permissions, I got hundreds of messages like this : "Open Error 6: Device not configured on" and then a list of paths, such as "System/Library/Perl/5.10.0/darwin-thread-multi-2level/auto/POSIX/getgrgld.al", and "System/Library/Frameworks/Ruby.framework/Versions/1.8/usr/share/ri/....." etc. Literally hundreds of those messages.
Does anyone know what this means? And how should I fix it?!?
Thanks!

I'm going to suggest that you ask in the Snow Leopard forums here:
http://discussions.apple.com/category.jspa?categoryID=263
This is likely a system software error, and the SL gurus that hang out over there might have suggestions for you.
Good luck!

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