"open with" menu suddenly showing multiple copies of all apps - HELP!!

Recently, the "open with" menu that pops up when I right click a file on my desktop has started showing multiple copies of all applications, and it's getting WORSE! It started out a few weeks ago doing this with one extra copy of only one application, but now there many, many copies of all apps - different numbers of copies depending on the app.
This is somehow related to the fact that I have an external G-Drive USB connected, which I am using as my backup drive. I copied everything onto this drive using SuperDuper. When the G-drive is connected, I get the error message below  if I pick the "wrong" copy of an app. When I eject the G-Drive, I STILL see multiple apps, but get no error message, and any one of the app copies I select will open properly.
IMac G5, PPC, OSX 10.4.11
Thank you for any help!

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