Opening application first time warning comes up every time

Since upgrading to snow leopard I get the "You are opening the application----- for the first time" dialog box every time I open some applications (not sure if it does it on all apps)
Is there a fix for stopping this?
Thanks, David

Thanks for the quick reply. I tried what you suggested but it didn't help. So far I've noticed this problem with Across Lite V2.0 (new york times crossword application) and filemaker pro 7.0
The permissions looked OK on Across Lite but it won't open by double clicking the App icon (box comes up saying the app is damaged) The program opens by double clicking the individual puzzle files (along with the "opening first time warning". I tried downloading a new Across Lite App but it does the same thing.
I noticed a small cloudy spot on the Snow Leopard upgrade disk. Could this cause behavior problems? Or would it not load at all if there was a flaw?
Any ideas?
Thanks, David

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