Optical drive won't install programs from CDs

I have a S300-EZ2501. I downgraded my installation from Vista Business to XP Pro.
My drive has stopped installing programs that come on CDs. I did not have this problem while loading all my software onto the laptop. Now, however, when I insert an installation CD into the drive, it attempts to read the CD, but cannot initialize the Autorun file, so nothing happens. I've tried running the install from the Run line, or by browsing to the file, but that does not work either. I also tried deleting the device from my system and reinstalling; that didn't work either.
Are there any registry settings for the optical drive that I can check? I want to make sure that the system is pointing to the correct location.
Thank you.
Barry L. Lippitt

I tried to restore to earlier settings, but that did not help.
If I try to doubleclick on the executable file on the CD, the hard drive light goes on, but not the external drive light.
I'm starting to think this is a WindowsXP problem and not a drive problem. I copied the contents of one of the program CDs to my hard drive, and tried installing from that directory. When I double-click on the Setup.exe file, there is sporadic hard drive flashing light, but nothing happens. The programs install from .exe files and not .msi files, so its not a Windows Installer problem. What other settings can I check that affect running setup programs on the laptop?
As I'm typing this, all of a sudden the executable program screen appeared on the laptop (after about 10 minutes). Maybe it will install, but that's a very long time before it happens.
Nothing more happened (10 more minutes). When I closed the screens fromy my toolbar, I received a popup telling me that I am ending the "nonresponsive program 32-bit Setup Launcher." I think there is a problem with this file; when I tried to install other programs (16-bit, from earlier versions) and had to close them down, I received messages that the 16-bit system was unstable.
Is there a way to repair these files on my laptop? What might have destabilized them?
As a reminder back to the beginning of this thread, my laptop came with Vista Business installed, but I downgraded from the restore CD to WinXP Pro.

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