OracleOraDb10g_home1iSQL*Plus service is not starting..

Hi,
I am getting error while starting "OracleOraDb10g_home1iSQL*Plus" service. and my oracle is not stating. When i am trying to connect to oracle it is giving me following error
C:\Documents and Settings\patelpa>sqlplus
Error 6 initializing SQL*Plus
Message file sp1<lang>.msb not found
SP2-0750: You may need to set ORACLE_HOME to your Oracle software directory
I am running Oracle 10g on Windows 2003 SP2 server.
Every thing was working fine i have done of HP Service desk Integration Agent installation on the server and did restart and from then the service is not running.
I have tried "isqlplusctl start" command and it started perfectly fine and i have started database after that and i could connect to database from that session but.. not luck with service.
I have tried to do research on the forums but didn't got answer for the specific scenario i am in.
Thanks,
Pankit.

try unselecting it, save the changes, go back in and select it, save the changes. there is a problem with the path, so that should fix it. either that, or you can fix the PATH environment variable manually, putting all the correct oracle directories at the beginning, in the correct order.

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