OS won't boot after iTunes update

OS 10.5.8 end of day Software Update for iTunes. This morning system will not boot
- start up tone; Apple Logo & spinner, 1-2 minutes Apple logo changes to no entry symbol.
Tried to start with Shift key down, NG
Tried to start with PRAM keys, NG
Tried to start from system disc and C key, NG
Any thoughts??
Peter

D2C wrote:
Tried to start with Shift key down, NG
Tried to start with PRAM keys, NG
Tried to start from system disc and C key, NG
tried booting into _*safe mode*_ ?
JGG

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