OS X 10.8.2 - Disk I/O error triggered by Adobe Application Manager

Question

Hi all,
I've been experienceing some issues wince updating from 10.8.1 to 10.8.2 when using Adobe Creative Suite CS5.5 and CS6.
Since going onto 10.8.2, everytime I launch Adobe Application Manager to perfom updates and manage my installation my MacBook stops responding and I'm presented with beachball.
I can leave the system for an hour and the Adobe Application Manager finally launches, however its un-responsive.
I'm unable to force quite as the entire system stops repsonding.
I've been trying to pinpoint the exact cause, and without fail Adobe Application Manager triggers it.
Here is an extract from the system log that appears when I try to use Adobe Application Manager.
29/10/2012 10:28:22.000 kernel[0]: CoreStorageGroup::completeIORequest - error 0xe00002ca detected for LVG "Munkey" (52A623F9-3A52-49A0-9055-DBBE3F0F6D46), pv 94322727-7BBC-4879-9AEC-0DC57100EA39, near LV byte offset = 123945537536.
29/10/2012 10:28:22.000 kernel[0]: disk1: I/O error.
29/10/2012 10:28:22.000 kernel[0]: hfs_clonefile: cluster_read failed - 5
29/10/2012 10:29:29.000 kernel[0]: CoreStorageGroup::completeIORequest - error 0xe00002ca detected for LVG "Munkey" (52A623F9-3A52-49A0-9055-DBBE3F0F6D46), pv 94322727-7BBC-4879-9AEC-0DC57100EA39, near LV byte offset = 126514241536.
29/10/2012 10:29:29.000 kernel[0]: disk1: I/O error.
The error keeps repeating until I power down the machine.
At first alarm bells are ringing as this suggests my HD is about to drop dead. However on another user account everything works perfectly including Adobe Application Manager.
Things I've tried:
I've ran Disk utility from the recovery partition to both verify the disk and fix permissions. All OK
S.M.A.R.T. is verified
Use a different user - Which seems to be fine
Uninstalled both CS6 and CS5.5 removing using the option to delete all preferences - No change
Used CS cleaner from Adobe to ensure every last trace of CS is removed - No change
Temporarily removed my users entire preference folder - No change
Rebuilt the Spotlight Index - No change
PRAM Reset Mulitple times - No change
Used ONYX to clear out Application Caches - No change
Verified using SeaTools under Windows 7 bootcamped - All OK
Just wondered if anyone else is having similar problems, or better yet has resolved it.

Answer 1

I've finally managed to spend a bit of time investigating further. Turns out that the PDApp.log file found in ~/Library/Logs/ was corrupted and also a couple of non related items awell. Possibly caused by hard reset or something whilst it was being written to?
I found this out by borrowing an external, the copied by entire user folder to the external using cp -R. This alerted me to any files that couldn't be copied across.
cp: /Users/paul/Library/Logs/PDApp.log: Input/output error
cp: /Users/paul/Pictures/Aperture Library.aplibrary/Database/apdb/History.apdb: Input/output error
cp: /Users/paul/Pictures/Aperture Library.aplibrary/Masters/2012/06/07/20120607-205006/DSCF5046.JPG: Input/output error
It did take a while to delete these, then I emptied my trash, again it took a while. But finally I'm free of lockups and I can use Creative Suite again ;-)
Going to monitor my drive for a couple of months see if anything else corrupts. Fingers crossed.
Thanks for your input guys. Hope this helps other folks.