OS X crashing & screen distortion

Hi all,
I am running 10.6.4 and for some time now, after the update to .3 and .4 my iMac has been crashing. What happens is it freezes with the spinning beach ball and becomes unresponsive. The mouse still moves and if video / audio is running in the background I can still hear it playing. I have no option but to hold the power button in and switch off / on.
Does this sound familiar to anyone? Are there any fixes?
The last time it happened I was running iTunes, Mail and Safari (which was streaming Sky Sports from the Sky website).
Also, I occasionally get image / screen distortion where part of the screen stretches and then returns. Has anyone had that also?
Many thanks,
Ian

Alt + tab isn't the default app switcher hot key sequence; command + tab is. But since I asked specifically about the command + option + escape hot key sequence, I wonder if you are using an Apple keyboard or perhaps a non-Apple one with differently marked keys. If so, try both the mapped & unmapped versions of the keys -- IOW, try all the modifier key combinations.
Also try temporarily disconnecting all non-essential peripherals like external drives or printers. Try starting up in Safe Mode & try logging into a newly created temporary user account. If the beach balls don't happen with any of these things, let us know.

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      AMD Radeon HD 6490M - VRAM: 256 MB
      Color LCD 1440 x 900
      Intel HD Graphics 3000 - VRAM: 384 MB
    System Software:
      Mac OS X 10.6.8 (10K549) - Uptime: 0 days 0:17:11
    Disk Information:
      Hitachi HTS545050B9A302 disk0 : (465.76 GB)
      - (disk0s1) <not mounted>: 200 MB
      Macintosh HD (disk0s2) / [Startup]: 465.44 GB (152.43 GB free)
      MATSHITADVD-R   UJ-898 
    USB Information:
      Apple Inc. FaceTime HD Camera (Built-in)
      Apple Inc. BRCM2070 Hub
      Apple Inc. Bluetooth USB Host Controller
      Apple Inc. Apple Internal Keyboard / Trackpad
      Apple Computer, Inc. IR Receiver
    Thunderbolt Information:
      Apple, Inc. MacBook Pro
    Launch Daemons:
      [not loaded] com.adobe.fpsaud.plist Support
      [not loaded] com.adobe.SwitchBoard.plist Support
      [not loaded] com.microsoft.office.licensing.helper.plist Support
      [not loaded] org.eyebeam.SelfControl.plist Support
    Launch Agents:
      [not loaded] com.adobe.AAM.Updater-1.0.plist Support
      [not loaded] com.hp.messagecenter.launcher.plist Support
    User Launch Agents:
      [not loaded] com.adobe.AAM.Updater-1.0.plist Support
      [not loaded] com.google.keystone.agent.plist Support
      [not loaded] com.spotify.webhelper.plist Support
    User Login Items:
      GrowlHelperApp
      iTunesHelper
    Internet Plug-ins:
      JavaAppletPlugin: Version: 13.9.8 - SDK 10.6 Check version
      FlashPlayer-10.6: Version: 14.0.0.145 - SDK 10.6 Support
      QuickTime Plugin: Version: 7.6.6
      Flash Player: Version: 14.0.0.145 - SDK 10.6 Support
      SharePointBrowserPlugin: Version: 14.1.0 Support
      OnLiveGameClientDetector: Version: OnLiveGameClientDetector 1.0.0 Support
      Silverlight: Version: 5.0.61118.0 - SDK 10.6 Support
      iPhotoPhotocast: Version: 7.0 - SDK 10.7
    Safari Extensions:
      Missing e: Version: 2.14.3
    iTunes Plug-ins:
      Quartz Composer Visualizer: Version: 1.2
    User Internet Plug-ins:
      Picasa: Version: 1.0 - SDK 10.4 Support
    3rd Party Preference Panes:
      Flash Player  Support
      Growl  Support
    Top Processes by CPU:
          6% WindowServer
          1% fontd
          0% soffice
          0% coreservicesd
          0% usbmuxd
    Top Processes by Memory:
      344 MB WebProcess
      143 MB Safari
      135 MB soffice
      53 MB iCal
      45 MB WindowServer
    Virtual Memory Information:
      1001 MB Free RAM
      584 MB Active RAM
      381 MB Inactive RAM
      2.07 GB Wired RAM
      239 MB Page-ins
      0 B Page-outs
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