OSX 10.7.4. will not save ANY of my preferences (system or application -- Safari, Office, etc.)

I am running System OSX 10.7.4 on three different MacBooks.  It will not save any of my preferences (system or application based), passwords, log-ins and keychain. Even Safari did not save imported bookmarks.  I am running Office For Mac 2011 (v 14.2.1) and Outlook will work for a day or two and then I get a rebuild database error message, losing everything.  Word, et all, will not save any preferences, not even recent files.
I did a full erase and clean system reinstall and a fresh install of Office. This problem occurs on all 3 of my MacBook, 2- MacBook Pro’s and a MacAir.  One of the MacBook Pro’s is BRAND NEW. 
Any ideas, any fixes out there?

I have what seems to be a similar issue. Are you having other issues like mine?
Macbook air      11-inch, Late 2010
                        4 GB 1067 MHz DDR3
Software           Mac OS X Lion 10.7.4 (11E53)
I have updated the latest combi update from the apple site and still have the same issue.
No matter what I try every time I restart my Mac all my preferences and applications reset. (Also preferences don't save when exiting the preference folder)
For example when in >system preferences>general -untick the 'restore windows when quitting and re-open apps' I exit preferences and then go back in to check it has automatically reticked the box.
I have deleted 2 applications several times (including removing the icon from the dock) and each time after restarting it shows a question mark on the dock where I had deleted it from.
On restart I loose downloads and history in safai.
On restart it re opens documents and applications I have quite even after unticking the restore applications on restart box (the one that comes up when shutting down or restarting)
I have been trying to solve this for a month now and it really is frustrating the **** out of me.
helpppp pleaseee...

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