Outgoing mail queue fills with spam

I remember reading about how to fix this before - but cannot find the details now.
I have a server that is trying to send mail to non existant domains or non existant e-mail addressed. the mail is not originating from clients.
Typical entry in the mail queue is
Message ID: 60D7987570
Date: Thu Aug 17 06:18:36
Size: 34446
Sender: MAILER-DAEMON
Recipient(s) & Status:
[email protected]:
host mail.cncnet.net[210.53.130.195] said: 450 4.1.1 <[email protected]>: Recipient address rejected: User unknown in local recipient table (in reply to RCPT TO command
how can I sent the mail server up to just ditch this stuff in the first place.
Tim

Here is an extract from the logs. I think I understand this now and it works as it should - but perhaps you could confirm.
This message is clearly not stuck in the outgoing queue. From what I can see mail is received from a backup mail relay for a non existent user on this server. When we try to reject it back to sender, if the sender rejects with 550 we bin it.
I guess the problem is what to do when the receiving mail server fails to respond? I think eventually it times out and we delete the message. Is that correct?
Aug 18 15:27:00 server postfix/cleanup[20819]: 9F7AAE92EB: message-id=<000001c6c2d2$2aae8940$d73fa8c0@hpcsece>
Aug 18 15:27:00 server postfix/qmgr[17315]: 9F7AAE92EB: from=<[email protected]>, size=3353, nrcpt=1 (queue active)
Aug 18 15:27:00 server postfix/smtpd[20816]: disconnect from scanner.datacenta.net[217.33.105.206]
Aug 18 15:27:16 server postfix/smtpd[20827]: connect from localhost[127.0.0.1]
Aug 18 15:27:16 server postfix/smtpd[20827]: B7FA3E930E: client=localhost[127.0.0.1]
Aug 18 15:27:16 server postfix/cleanup[20819]: B7FA3E930E: message-id=<000001c6c2d2$2aae8940$d73fa8c0@hpcsece>
Aug 18 15:27:16 server postfix/qmgr[17315]: B7FA3E930E: from=<[email protected]>, size=3905, nrcpt=1 (queue active)
Aug 18 15:27:16 server postfix/smtpd[20827]: disconnect from localhost[127.0.0.1]
Aug 18 15:27:17 server postfix/smtp[20820]: 9F7AAE92EB: to=<[email protected]>, relay=127.0.0.1[127.0.0.1], delay=18, status=sent (250 2.6.0 Ok, id=20277-06, from MTA: 250 Ok: queued as B7FA3E930E)
Aug 18 15:27:17 server postfix/qmgr[17315]: 9F7AAE92EB: removed
Aug 18 15:27:17 server postfix/lmtp[20828]: B7FA3E930E: to=<[email protected]>, relay=/var/imap/socket/lmtp[/var/imap/socket/lmtp], delay=1, status=bounced (host /var/imap/socket/lmtp[/var/imap/socket/lmtp] said: 550-Mailbox unknown. Either there is no mailbox associated with this 550-name or you do not have authorization to see it. 550 5.1.1 User unknown (in reply to RCPT TO command))
Aug 18 15:27:17 server postfix/cleanup[20819]: 38178E9310: message-id=<[email protected]>
Aug 18 15:27:17 server postfix/qmgr[17315]: 38178E9310: from=, size=6025, nrcpt=1 (queue active)
Aug 18 15:27:17 server postfix/qmgr[17315]: B7FA3E930E: removed
Aug 18 15:27:19 server postfix/smtp[20831]: 38178E9310: to=<[email protected]>, relay=bx1.techsolsc.com[65.5.144.18], delay=2, status=bounced (host bx1.techsolsc.com[65.5.144.18] said: 550 <[email protected]>: Recipient address rejected: Unknown user (in reply to RCPT TO command))
Aug 18 15:27:19 server postfix/qmgr[17315]: 38178E9310: removed

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