Outlook Anywhere Loosing connection : Outlook Event id 26 and Exchange IIS HTTPERR Log : Connection_Dropped_List_Full at the same time

Hi,
I have a Windows 2008R2 Updated / Exchange 2010 SP3 Rollup 7 (Role CAS,HUB,MBX) with only external users connection : ActiveSync, EWS, OWA, Outlook Anywhere.
4 processors and 24Go of memory are allocated to the Exchange server VM (VMWare).
Netscaller is used as reverse proxy in DMZ.
There is around 500 users connecting with Outlook Anywhere to Exchange. Users are using Outlook 2010 or 2013 with last updates and cache mode enabled (owner mailbox and delegations). Users are location all around the world (around 50 sites). So no users
is domain integrated.
Users are complaining about disconnection, and Outlook freeze (Outlook is not responding). This happened at any point of time during the day, and for different kind of actions (Outlook is just open, Try to press Send button, try to press Transfer button).
The freeze happened randomly for users. I have seen the problem, and Outlook sometimes freeze during few seconds, sometimes during 5 minutes without any reason. (no file copy, no action asked...)
I noticed that freeze are matching with the Outlook event id 26 on the workstation (Connection to the Microsoft Exchange Server has been lost. Outlook will restore the connection when possible). Also, at the same time, I can see around 200 lines in
the IIS HTTPERR Log (Exchange Server : C:\Windows\System32\LogFiles\HTTPERR) the following lines:
2014-11-20 10:39:43 NETSCALLERIP PORT EXCHANGEIP 443 HTTP/1.1 RPC_OUT_DATA /rpc/rpcproxy.dll?EXCHANGEFQDN:6004 - 1 Connection_Dropped_List_Full MSExchangeOutlookAnyWhere
2014-11-20 10:39:43 NETSCALLERIP PORT EXCHANGEIP 443 HTTP/1.1 RPC_OUT_DATA /rpc/rpcproxy.dll?EXCHANGEFQDN:6001 - 1 Connection_Dropped_List_Full MSExchangeOutlookAnyWhere
What has been already checked :
Check IOPS: seems to be normal
Check Processor consumption: seems to be normal
Netscaller TimeOut = 8h
Bandwidth where the server is hosted : more than enough
Bandwidth of client internet connection : Traffic do not increase when the problem happen
Firewall TimeOut : seems to be ok
Firewall Protocol Filter : seem to be ok
Workstation MTU : Ok : ping -l -f 1472 = Ok, so best MTU = 1500 (1472+28)
Outlook Profile : Clean Up OST, sync of all folders, download address book.
wireshark on workstation : nothing seems to be wrong but difficult to analyse, so I maybe missed something.
Configuration change on Exchange :
HKLM\Software\Policies\Microsoft\Windows NT\RPC\MinimumConnectionTimeout = 120
Disable throttling Policy
Adsiedit, change Max Memory alloc for ESE : msExchESEParamCacheSizeMax = 327680 (around 10GB) msExchESEParamCacheSizeMin = 131072 (around 4GB
Adsiedit, change Min Memory alloc for ESE : msExchESEParamCacheSizeMin = 131072 (around 4GB)
Host file : add hostname and FQDN of Exchange Server
Disable IPV6 : HKLM\System\CurrentControlSet\services\TCPIP6\Parameters\DisabledComponents = HEX 0xffffffff
IIS : system.applicationHost : webLimits : minBytesPerSecond = 0
Create dedicated IIS AppPool MSExchangeOutlookAnyWhere for /RPC and /RPCWithCert
AppPool MSExchangeOutlookAnyWhere : Regular Time Interval (minutes) : 0
AppPool MSExchangeOutlookAnyWhere : Queue Length : 20000 (Should be the solution but not working)
netsh int tcp set global chimney=disabled
netsh int tcp set global rss=disabled
HKLM\SYSTEM\CurrentControlSet\Services\Tcpip\Parameters\MaxUserPort = 65534
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip\Parameters\KeepAliveTime : 300000
HKLM\SYSTEM\CurrentControlSet\Services\Netlogon\Parameters\MaxConcurrentAPI = 150
IIS machine.config : <system.web> : requestQueueLimit="65535"
Microsoft.Exchange.RpcClientAccess.Service.exe.config <add key=”LoggingTag” value=”ConnectDisconnect, Logon, Failures, ApplicationData, Warnings, Throttling”/>
Uninstall All agents (except Backup Agent)
Uninstall Antivirus
Will be done tonight :
Exchange and DCs : HKLM\SYSTEM\CurrentControlSet\Services\Netlogon\Parameters\MaxConcurrentAPI = 100
Exchange IIS : Increase AppPool MSExchangeOutlookAnyWhere Queue Length to 40000
Exchange : decrease HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip\Parameters\KeepAliveTime to 60000
You're welcome if you have any idea.
Thanks.
Jo.

Hi,
Thanks for your answer. Here are my comments :
1. Disable IPv6 then restart your Exchange server
Already done since the install of Exchange.
2. Confirm if there is any NLB device in your environment, please remove NLB firm client server
There is only one Exchange server in the Org. So no NLB installed on the server (NLB is used on the Netscaller used as a reverse proxy). In Addition, the article apply for Windows 2008, or the server is installed with Windows 2008 R2.
3. If there is a proxy server configured in IE, please uncheck it
I guess you are talking on the client side. There is no proxy on the client side, Outlook Anywhere connect directly to the internet.
4. Collect more error logs in Event Viewer in Exchange and collect the IIS logs in
folder “c:\inetpub\logs\logfiles\W3SVC1”
the error I reported in the description is from IIS, and always appear when end users report a problem. In W3SVC1 file, there is also errors, but those one appear even if Outlook clients are working fine. So I cannot isolate any specific
error. The most common from W3SVC1 log are :
2014-11-25 08:02:17 EXCHANGEIP POST /autodiscover/autodiscover.xml - 443 - NETSCALLERIP Microsoft+Office/15.0+(Windows+NT+6.1;+Microsoft+Outlook+15.0.4667;+Pro)
401 1 2148074254 0
2014-11-25 08:02:17 EXCHANGEIP POST /EWS/Exchange.asmx - 443 - NETSCALLERIP Mac_OS_X/10.9.5+(13F34)+CalendarAgent/176.2
401 1 2148074254 0
2014-11-25 08:02:18 EXCHANGEIP POST /EWS/Exchange.asmx - 443 - NETSCALLERIP Microsoft+Office/14.0+(Windows+NT+6.1;+Microsoft+Outlook+14.0.7128;+Pro)
401 1 2148074254 0
Regards,
Jo.

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Outlook Anywhere Loosing connection : Outlook Event id 26 and Exchange IIS HTTPERR Log : Connection_Dropped_List_Full at the same time

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