PB acting goofy - Openin Application Error Message - refusing to print

I was using Adobe Photoshop CS yesterday and noticed some of my usual tools were suddenly missing (grayed out). I figured it was a fluke, and didn't really worry about it.
Then today, I am getting error messages for other programs (Mail, Adobe Acrobat Pro, Adobe InDesign CS, etc.) saying, "You are opening the application 'Acrobat Professional' (or whichever program) for the first time. Are you sure you want to open this application?" I have had these programs for years, and use them regularly. I've never ran across this before.
I also have two printers (HP Color LaserJet 2550n, Brother IntelliFAX 2820), and every time I try to print on either printer, it tells me the printer's memory is full and it's unable to print.
I have not done anything to my computer, other than the usual weekly maintenance with OnyX, repairing permissions, etc. which was done a week ago. I have been on OS Tiger for over a year now. I checked my S.M.A.R.T status last Thursday, and all was good.
As I am deaf, I depend on my PowerBook to communicate with other people, and to get my work done. The computer was working fine until yesterday.
Thank you so much in advance for any help and suggestions.

Robbi:
I would begin by running Repair Disk
Insert Installer disk and Restart, holding down the "C" key until grey Apple appears.
Go to Installer menu (Panther and earlier) or Utilities menu (Tiger) and launch Disk Utility.
Select your HDD (manufacturer ID) in the left panel.
Select First Aid in the Main panel.
(Check S.M.A.R.T Status of HDD at the bottom of right panel, and report if it says anything but Verified)
Click Repair Disk on the bottom right.
If DU reports disk does not need repairs quit DU and restart.
If DU reports errors Repair again and again until DU reports disk is repaired.
If DU reports errors it cannot repair you will need to use a utility like Tech Tool Pro or Disk Warrior
Do you have the original Hard Disk Drive in this computer?
What is the total capacity of your HDD and how much available capacity? (select Macintosh HD on desktop, then Get Info (Command + I))
cornelius

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