PDF Files from InDesign much larger than Quark- Distiller, why?

We've recently switched our publishing workflow for one of our pubs from Quark to InDesign, and are having issues with PDFs being really large. Previously, the pub would be PS'd out of QXP6.52 and then ran through our Distiller service at Press Ready quality settings. The resulting PDF files were 4-6mb (This is only a 2-page pub).
Now, moving to InDesign, we PDF directly from InDesign (or I've also tried PSing and then Distilling), and using Press Ready Quality settings still -- the resultant PDF files are 15-16mb. Can anyone theorize as to what would create such a large difference between the two?
This is using a few issues of the pub - not just one instance, as well.
Thanks

[email protected] wrote:
7. Yes, the file and links are using transparency.
This is probably the answer.
Recreate the page in InDesign with no transparency (as a test). This means all links are tiff or eps. No use of opacity or blend modes. No drop shadows.
This is how it would have been in Quark 6, which did not support transparency (the newer kind anyway)
Note: if you had overlying drop shadows in Quark 6 they would have had to have been bitmap tiffs.
I also should mention: transparency is a good thing. There may be a way to get the file size down without removing transparency. Possibly you could use Acrobat to do this.
Also note I posted a couple of updates on my previous post, they may or may not be relevant.

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