PDF/Keynote will not work and IMac (2009) Lion 10.7.5  is extremely slow

Both MBP 15" 2010 and IMac 2009 - both Lion 10.7.5 are slow
I do not have a lot of garbage on them- I try to be careful about the sites that I visit (in school so I usually visit sites through the university's VPN)
This is driving me insane!

Hi, on the slowness...
See if the Disk is issuing any S.M.A.R.T errors in Disk Utility...
http://support.apple.com/kb/PH7029
Open Activity Monitor in Applications>Utilities, select All Processes & sort on CPU%, any indications there?
How much RAM & free space do you have also, click on the Memory & Disk Usage Tabs.
Open Console in Utilities & see if there are any clues or repeating messages when this happens.
In the Memory tab of Activity Monitor, are there a lot of Pageouts?

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