PDF quality is degraded when InDesign file is reopened.

When I place PDF files in my InDesign document and print, or save to PDF immediately, the quality is great.
However, if I save the InDesign file and open it later, the PDF quality is much degraded. Too degraded to use.
I must make the document or book all over again.
Why does the PDF quality degrade when re-opening the InDesign?
HOW CAN I PREVENT THIS?
Thanks.

Regarding Peter's "be sure the link is up to date" because I was typing this after he posted:
Try placing a PDF into an ID doc, save the InDesign file, then reopen it. Select your placed file with the black selection tool, then go Window and select the Links panel. Looking at your linked image will tell you if InDesign can no longer find the image in the original location. (There'd be a yellow triangle with an exclamation point to indicate that the link is missing.)  When you place your PDF into InDesign, a 72ppi preview of your linked file is saved in the INDD. In order to print, or export a good quality PDF, InDesign needs to be able to find the linked file.
So when you reopen, ID for some reason can't find the file. This could be caused by a wide variety of issues, but the most likely is that you moved either the InDesign file, or the linked PDF. Or perhaps your linked PDF is on an unavailable network drive? If you tell us more about your working environment, we might be able to figure out why the link is breaking.

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