PDF won't open in Acrobat after Saving in illustrator

Hi I am currently working on my final architecture project and am having issues with opening a PDF in acrobat after editing and saving in Illustrator.
I am creating an architecture document in autocad which I then export to PDF to be edited in Illustrator. It opens fine in illustrator, however once I have edited and saved in illustrator I am unable to open in acrobat and the program just crashes.
After editing in illustrator the file size increases fairly substantially, but I am able to open larger PDF files no problem if they have no been edited in Illustrator.
Any help would be great. Let me know if any further information would help?
Thanks!

Hi Graffiti,
I have posted it in the windows one as I am using Autocad in windows to create the origional PDF. However this has not caused any problems until now.
In answer to your other questions I have used 'save' and 'save as' and tried saving under new file names.
I have been saving the PDF rather than using the PDF printer.
Let me know if any other info would help.

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PDF won't open in Acrobat after Saving in illustrator

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