Performance Issue with BPC MS 7.0

We are receiving error: "The underlying connection was closed:Unable to connect to the remote server.", when we optimize the application  or full processing the dimension. But, according to the TblLogs file the full optimizations are completing successfully although the client side error is received.
In Pre prod, when we tried to do all the above activities without citrix i.e., through the client installed on Server , we have not faced any hassels. It went fine. We are about to implement this in the Prod to isolate the issue. Problem while accessing the app through Citrix.
SAP also recommends to review the configuration of your Network Load Balanced (NLB) environment (WEB01) or Citrix deployment of BPC. But our teams says, everything is fine from their point. There is no flaw observed.
Paralelly, we have Increased Connection Time out levels @ IIS server level. Earlier it was 600 , we made it as 1200. Did Tbl logs table cleared. We have increased Time out Settings at DB level and OLAP level also as recommended by SAP. But no change in the error.
Any clue, what could be the reason for this after having the detailed investigation on the error as mentioned above.
This is so urgent, almost 150 users are getting effected.
Your immediate help would be appreciated.
FYI, we are using  BPC MS 7.0 SP12 and SQl Server 2008.
Many Thanks
Naga Jyothi

Hi Naga Jyothi,
this is a microsoft error message, there is probably an error on IIS settings or .NET.
If you filter the search on MS site you will found a lot of relevant threads, e.g. see
http://support.microsoft.com/kb/915599
(remember to check with your .NET framework)
Regards
     Roberto

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    Report generated 7 maart 2015 14:16:18 CET
    Download EtreCheck from http://etresoft.com/etrecheck
    Click the [Click for support] links for help with non-Apple products.
    Click the [Click for details] links for more information about that line.
    Hardware Information: ℹ️
        iMac (27-inch, Mid 2011) (Technical Specifications)
        iMac - model: iMac12,2
        1 3.4 GHz Intel Core i7 CPU: 4-core
        16 GB RAM Upgradeable
            BANK 0/DIMM0
                4 GB DDR3 1333 MHz ok
            BANK 1/DIMM0
                4 GB DDR3 1333 MHz ok
            BANK 0/DIMM1
                4 GB DDR3 1333 MHz ok
            BANK 1/DIMM1
                4 GB DDR3 1333 MHz ok
        Bluetooth: Old - Handoff/Airdrop2 not supported
        Wireless:  en1: 802.11 a/b/g/n
    Video Information: ℹ️
        AMD Radeon HD 6970M - VRAM: 1024 MB
            iMac 2560 x 1440
    System Software: ℹ️
        OS X 10.9.4 (13E28) - Time since boot: 0:19:51
    Disk Information: ℹ️
        WDC WD1001FALS-403AA0 disk1 : (1 TB)
            EFI (disk1s1) <not mounted> : 210 MB
            MacintoshHD2  (disk1s2) /Volumes/MacintoshHD2  : 999.86 GB (152.18 GB free)
        APPLE SSD TS256C disk0 : (251 GB)
            EFI (disk0s1) <not mounted> : 210 MB
            MacintoshHD (disk0s2) / : 250.14 GB (62.97 GB free)
            Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
        HL-DT-STDVDRW  GA32N 
        HGST HDS724040ALE640 disk2 : (4 TB)
            EFI (disk2s1) <not mounted> : 210 MB
            disk2s2 (disk2s2) <not mounted> : 4.00 TB
            Boot OS X (disk2s3) <not mounted> : 134 MB  - one error
        HGST HDS724040ALE640 disk3 : (4 TB)
            EFI (disk3s1) <not mounted> : 210 MB
            disk3s2 (disk3s2) <not mounted> : 4.00 TB
            Boot OS X (disk3s3) <not mounted> : 134 MB
    USB Information: ℹ️
        Mitsumi Electric Hub in Apple Extended USB Keyboard
            Logitech USB-PS/2 Optical Mouse
            Mitsumi Electric Apple Extended USB Keyboard
        Apple Inc. BRCM2046 Hub
            Apple Inc. Bluetooth USB Host Controller
        Apple Inc. FaceTime HD Camera (Built-in)
        Lexar  USB_3_0 Reader 
        Seagate  Expansion Desk 3 TB
            EFI (disk5s1) <not mounted> : 315 MB
            downloads (disk5s2) /Volumes/downloads : 249.18 GB (138.35 GB free)
            BackUpBro (disk5s3) /Volumes/BackUpBro : 2.75 TB (1.03 TB free)
        Apple Computer, Inc. IR Receiver
        Apple Internal Memory Card Reader
    Thunderbolt Information: ℹ️
        Apple Inc. thunderbolt_bus
            G-Technology G-RAID with Thunderbolt
    Configuration files: ℹ️
        /etc/sysctl.conf - Exists
    Gatekeeper: ℹ️
        Mac App Store and identified developers
    Kernel Extensions: ℹ️
            /Applications/Toast 11 Titanium/Spin Doctor.app
        [not loaded]    com.hzsystems.terminus.driver (4) [Click for support]
            /Library/Extensions
        [not loaded]    com.Avid.driver.AvidDX (5.9.1 - SDK 10.8) [Click for support]
        [not loaded]    com.blackmagic-design.desktopvideo.iokit.driver (10.1.4 - SDK 10.8) [Click for support]
        [not loaded]    com.blackmagic-design.desktopvideo.iokit.framebufferdriver (10.1.4 - SDK 10.8) [Click for support]
        [not loaded]    com.blackmagic-design.desktopvideo.multibridge.iokit.driver (10.1.4 - SDK 10.8) [Click for support]
        [not loaded]    com.blackmagic-design.driver.BlackmagicIO (10.1.4 - SDK 10.8) [Click for support]
            /Library/Extensions/DeckLink_Driver.kext/Contents/PlugIns
        [not loaded]    com.blackmagic-design.desktopvideo.firmware (10.1.4 - SDK 10.8) [Click for support]
            /System/Library/Extensions
        [not loaded]    at.obdev.nke.LittleSnitch (3876 - SDK 10.8) [Click for support]
        [not loaded]    com.SafeNet.driver.Sentinel (7.5.2) [Click for support]
        [not loaded]    com.paceap.kext.pacesupport.master (5.9.1 - SDK 10.6) [Click for support]
        [not loaded]    com.roxio.BluRaySupport (1.1.6) [Click for support]
            /System/Library/Extensions/PACESupportFamily.kext/Contents/PlugIns
        [not loaded]    com.paceap.kext.pacesupport.leopard (5.9.1 - SDK 10.4) [Click for support]
        [not loaded]    com.paceap.kext.pacesupport.panther (5.9.1 - SDK 10.-1) [Click for support]
        [loaded]    com.paceap.kext.pacesupport.snowleopard (5.9.1 - SDK 10.6) [Click for support]
        [not loaded]    com.paceap.kext.pacesupport.tiger (5.9.1 - SDK 10.4) [Click for support]
            /Users/[redacted]/Library/Services/ToastIt.service/Contents/MacOS
        [not loaded]    com.roxio.TDIXController (2.0) [Click for support]
    Startup Items: ℹ️
        Digidesign Mbox 2: Path: /Library/StartupItems/Digidesign Mbox 2
        DigidesignLoader: Path: /Library/StartupItems/DigidesignLoader
        Startup items are obsolete in OS X Yosemite
    Problem System Launch Agents: ℹ️
        [running]    com.paragon.NTFS.notify.plist [Click for support]
    Launch Agents: ℹ️
        [not loaded]    com.adobe.AAM.Updater-1.0.plist [Click for support]
        [loaded]    com.adobe.CS4ServiceManager.plist [Click for support]
        [running]    com.avid.ApplicationManager.plist [Click for support]
        [running]    com.avid.backgroundservicesmanager.plist [Click for support]
        [loaded]    com.avid.dmfsupportsvc.plist [Click for support]
        [loaded]    com.avid.interplay.dmfservice.plist [Click for support]
        [loaded]    com.avid.interplay.editortranscode.plist [Click for support]
        [loaded]    com.avid.transcodeserviceworker.plist [Click for support]
        [running]    com.blackmagic-design.DesktopVideoFirmwareUpdater.plist [Click for support]
        [failed]    com.brother.LOGINserver.plist [Click for support] [Click for details]
        [loaded]    com.paragon.updater.plist [Click for support]
        [failed]    com.teamviewer.teamviewer.plist [Click for support] [Click for details]
        [failed]    com.teamviewer.teamviewer_desktop.plist [Click for support]
    Launch Daemons: ℹ️
        [loaded]    com.adobe.fpsaud.plist [Click for support]
        [loaded]    com.adobe.SwitchBoard.plist [Click for support]
        [loaded]    com.adobe.versioncueCS4.plist [Click for support]
        [loaded]    com.avid.AMCUninstaller.plist [Click for support]
        [running]    com.avid.interplay.editorbroker.plist [Click for support]
        [running]    com.avid.interplay.editortranscodestatus.plist [Click for support]
        [loaded]    com.blackmagic-design.desktopvideo.XPCService.plist [Click for support]
        [running]    com.blackmagic-design.DesktopVideoHelper.plist [Click for support]
        [running]    com.blackmagic-design.streaming.BMDStreamingServer.plist [Click for support]
        [not loaded]    com.digidesign.fwfamily.helper.plist [Click for support]
        [running]    com.edb.launchd.postgresql-8.4.plist [Click for support]
        [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
        [loaded]    com.noiseindustries.FxFactory.FxPlug.plist [Click for support]
        [loaded]    com.noiseindustries.FxFactory.plist [Click for support]
        [running]    com.paceap.eden.licensed.plist [Click for support]
        [loaded]    com.teamviewer.Helper.plist [Click for support]
        [failed]    com.teamviewer.teamviewer_service.plist [Click for support]
        [loaded]    jp.co.canon.MasterInstaller.plist [Click for support]
        [loaded]    PACESupport.plist [Click for support]
    User Login Items: ℹ️
        iTunesHelper    Programma Hidden (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
    Internet Plug-ins: ℹ️
        Default Browser: Version: 537 - SDK 10.9
        OfficeLiveBrowserPlugin: Version: 12.2.6 [Click for support]
        AdobePDFViewerNPAPI: Version: 11.0.0 - SDK 10.6 [Click for support]
        FlashPlayer-10.6: Version: 16.0.0.305 - SDK 10.6 [Click for support]
        Silverlight: Version: 5.1.30514.0 - SDK 10.6 [Click for support]
        Flash Player: Version: 16.0.0.305 - SDK 10.6 [Click for support]
        QuickTime Plugin: Version: 7.7.3
        iPhotoPhotocast: Version: 7.0 - SDK 10.8
        SharePointBrowserPlugin: Version: 14.0.0 [Click for support]
        AdobePDFViewer: Version: 11.0.0 - SDK 10.6 [Click for support]
        EPPEX Plugin: Version: 10.0 [Click for support]
        JavaAppletPlugin: Version: 14.9.0 - SDK 10.7 Check version
    User internet Plug-ins: ℹ️
        Google Earth Web Plug-in: Version: 7.0 [Click for support]
    Audio Plug-ins: ℹ️
        DVCPROHDAudio: Version: 1.3.2
    3rd Party Preference Panes: ℹ️
        Blackmagic Desktop Video  [Click for support]
        DigidesignMbox2  [Click for support]
        Digidesign Mbox 2 Pro  [Click for support]
        Flash Player  [Click for support]
        Paragon NTFS for Mac ® OS X  [Click for support]
    Time Machine: ℹ️
        Skip System Files: NO
        Mobile backups: OFF
        Auto backup: NO - Auto backup turned off
        Volumes being backed up:
            MacintoshHD: Disk size: 250.14 GB Disk used: 187.17 GB
            downloads: Disk size: 249.18 GB Disk used: 110.83 GB
        Destinations:
            G-RAID with Thunderbolt [Local]
            Total size: 8.00 TB
            Total number of backups: 6
            Oldest backup: 2014-04-08 14:24:41 +0000
            Last backup: 2014-09-24 21:58:28 +0000
            Size of backup disk: Excellent
                Backup size 8.00 TB > (Disk size 499.32 GB X 3)
    Top Processes by CPU: ℹ️
             2%    WindowServer
             1%    fontd
             0%    firefox
             0%    AvidApplicationManager
             0%    AppleSpell
    Top Processes by Memory: ℹ️
        498 MB    firefox
        241 MB    mds_stores
        172 MB    com.apple.IconServicesAgent
        137 MB    Dock
        100 MB    java
    Virtual Memory Information: ℹ️
        12.33 GB    Free RAM
        2.39 GB    Active RAM
        1.11 GB    Inactive RAM
        1.34 GB    Wired RAM
        934 MB    Page-ins
        0 B    Page-outs
    Diagnostics Information: ℹ️
        Mar 7, 2015, 01:56:19 PM    Self test - passed
        Mar 6, 2015, 08:15:56 PM    /Library/Logs/DiagnosticReports/Mail_2015-03-06-201556_[redacted].hang

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