Photoshop CC Save is greyed out

Hi,
I have noticed on occasion that an image I have been working on in Photoshop CC v14.0 will have the Save option greyed out even though changes have been made.
Usually when I make only a few small changes to an existing image, as opposed to starting to combine a new file.
A couple of times I have been caught out hitting Command + S and then closing my image only to find the work I had done was not saved.
I first tweaked onto this problem when I send an adjusted image to a client and he responded asking why the changes were not made - not good.
I do not know why this should happen, the save button surely is pretty much the most important one there is
and for it to not be functioning correctly is frankly beyond appalling, and completely and totally unacceptable.
Has anyone else been plagued with this problem?
Does anyone have a solution?
Prefs:
Save in Background = ON
Automatically Save Recovery Information Every = OFF
Running PS CC v14.0
Mac Pro 10.8.4

Thanks!  That worked.
Doug Sturgess
770-329-3199
Website:  http://www.sturgessart.com
Blog:  http://sturgessart.com/blog
Online ordering:  http://doug-sturgess.artistwebsites.com

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