Photoshop CS 5 12.0.4 stopped opening any images but JPEG's!

Running a MacBook Pro, 17in, 2.93 Dual Core Intel, 8 GB RAM, OS 10.6.8.  All programs and plugins are 64 bit compatable and have worked just fine for months and months.
I've been using PS 5 and LR 4.1 for a LONG time. I have several NIK plugins, non new.  As of today, Photoshop will NOT open RAW/NEF, TIF, DNG files directly or by sending the file to PS from LR 4.1.
The only update was a month ago when I upgraded ACR to 6.7.0 to read NEF's from my new Nikon D4. PS won't open files from older camera's either.
This JUST started happening today, June 9th!  Worked fine June 8th, not today.  The message is ALWAYS Photoshop Not Responding.
HELP!!
Alan

Curt, this morning Bridge would freeze and not send images to ACR, except JPG's.  I disabled the whole Plugin folder, then just the NIK plugin folder, the exact same results, Photoshop CS5 freezes!
I download Adobe DNG converter 6.5, converted some NEF's to dng's and they still won't open.
I download CS6 & Bridge, ACR 7.1 and it freezes when trying to open anything, including JPG's, so that's worse not better ;~(.  Did a complete "uninstall" of PS6. Removed the newest ACR 7.1 and Bridge, went back to original versions for PS 5.
For reasons only known to Adobe or Apple the darn software; LR 4.1 and PS 5 Extended are now working perfectly WITH the plugin's (I removed the "updates" from NIK) which were before the "update"!!
Again Curt, thanks for the advice and I honestly have NO CLUE why the software has choosen to work again... I think a reformat of my hard drive and install of Snow Leopard again is soon going to be necessary ;~(.  I hate doing that because trying to find all the serial # for software is tough, at least for me LOL.
I use DataBackup from Prosoft now but I'm thinking of doing a clean BU using TimeMachine. I need a BU that will retain application serial numbers, any idea on that one??  I've gone to my Adobe site and gotten the serials I need there, and I've got them from NIK, but I have a LOT more installed from download (no disc's).
Alan

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