Photoshop CS3 won't start anymore

I use Photoshop CS3 with OSX 10.4.  Everything has been working great until reccently.  I had a huge job and the amount of memory it took was causing 'scratch dick full' errors.  One day I pulled Photoshop up and it got part way through opening and crashed.  It has been doing this ever since.  I have cleared over 22 gig of space, cleared the preferences by holding down the control, option, shift.... when starting, and finally reinstalled Photoshop.  Nothing works.  All of my other software is working great.  However, I also have CS2 and Photoshop isn't starting on that version either.
What can I do to get it going again?  I have jobs backed up and I'm falling behind fast!
Any help appreciated!

Press and hold Ctrl - Shift - Alt IMMEDIATELY after starting Photoshop from its menu item or shortcut.  This will allow you to reset the preferences to initial defaults.
I'm betting that will help.
-Noel

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