Photoshop CS5.5 Layers partially disappear. Cannot get them back.

Adobe CS5.5 Photoshop running on Mac OS X.
This is a brand new installation, just purchased and installed last week, and this is the first graphic heavy task I have attempted using Photoshop CS5.5. I was working in a document (photo-manipulation) and eveyrthing was going very, very smoothly. I was using mostly Masks. The issue ocurred immediately after I tried to apply a Hue/Saturation effect to the topmost layer. All the layers experienced partial disappearing. Even though they appear whole in the layers tab, on the stage huge parts are missing.
See this screenshot:
I tried to undo the Hue/Saturation, close Photoshop completely and reopen, and double checking the settings on each layer. I was saving as I went along but even closing without saving and re-opening the file did not help much. Most of the disppeared portions have returned, but there are still "chunks", sort to speak, that are "missing". I have spent about four hours on this piece so far, and I really do not want to have to go back and re-do the "missing" parts (that are not really missing just not showing up). And the layer with the knight is not supposed to be black, Photoshop did that all on its own. O.o
Has anyone else experienced this? Is there a way to get all of each layer back visible? I have used Photoshop CS2 and I have Photoshop CS4 on my other computer, but I have never had this happen in any of the earlier versions. And this being the first time I used Photoshop CS5.5 for more than just saving screenshots... Yeah. Any ideas?
~Jacquelyn

On your recommendation, I tried turning off the OpenGL and restarted Photoshop. I also checked the blend settings. No change. I am beginning to think that perhaps the missing "chunks" on the various layers were somehow deleted. Though I did not select nor delete anything. It is very curious. I wish I knew what happened (or what I did by accident) so I can prevent this type of thing from happening in the future.
Anyway, I spent a few extra hours re-doing the parts that were "missing" and now the piece is finished. http://fav.me/d49b0sz
~Jacquelyn

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