Photoshop CS5 - brushes, blur slow in higher resolution

Hi,
My Dad recently upgraded his monitor from an old CRT on 1024x768 resolution to a new LCD with 1920x1080 resolution, and he's found that tools that require the use of the mouse are running particularly slowly now. He's using Photoshop on a Windows Vista 64-bit machine with 4GB RAM and around 3.5TB of storage space. Do you know why the sluggishness might be occurring?
Thanks!

Maybe he's using brushes which are twice as large as before because he has about twice as many pixels across the screen now. A round brush will fill four times as many pixels with each doubling of its size, therefore the computer will appear to be four times slower. I better say that's a crude approximation before somebody jumps on my case with a computer science lecture.

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Adobe Photoshop Version: 12.1 (12.1x20110328 [20110328.r.145 2011/03/28:10:30:00 cutoff; r branch]) x64
Operating System: Windows NT
Version: 6.2
System architecture: Intel CPU Family:6, Model:10, Stepping:9 with MMX, SSE Integer, SSE FP, SSE2, SSE3, SSE4.1, SSE4.2
Physical processor count: 8
Processor speed: 3392 MHz
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Memory used by Photoshop: 60 %
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Image cache levels: 4
OpenGL Drawing: Enabled.
OpenGL Drawing Mode: Normal
OpenGL Allow Normal Mode: True.
OpenGL Allow Advanced Mode: False.
OpenGL Crash File: Not Detected.
OpenGL Allow Old GPUs: Not Detected.
Video Card Vendor: NVIDIA Corporation
Video Card Renderer: GeForce GTX 660/PCIe/SSE2
Display: 1
Display Bounds:= top: 0, left: 0, bottom: 1200, right: 1920
Video Card Number: 1
Video Card: NVIDIA GeForce GTX 660
Driver Version: 9.18.13.546
Driver Date: 20120731000000.000000-000
Video Card Driver: nvd3dumx.dll,nvwgf2umx.dll,nvwgf2umx.dll,nvd3dum,nvwgf2um,nvwgf2um
Video Mode:
Video Card Caption: NVIDIA GeForce GTX 660
Video Card Memory: 1536 MB
Serial number: 95478754394945338970
Application folder: C:\Program Files\Adobe\Adobe Photoshop CS5.1 (64 Bit)\
Temporary file path: C:\Users\MICK92~1\AppData\Local\Temp\
Photoshop scratch has async I/O enabled
Scratch volume(s):
Startup, 1.81T, 1.30T free
Primary Plug-ins folder: C:\Program Files\Adobe\Adobe Photoshop CS5.1 (64 Bit)\Plug-ins\
Additional Plug-ins folder: not set
Installed components:
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   AdobePIP.dll   Adobe Product Improvement Program   5.5.0.1265
   AdobeXMP.dll   Adobe XMP Core   5.0   64.140949
   AdobeXMPFiles.dll   Adobe XMP Files   5.0   64.140949
   AdobeXMPScript.dll   Adobe XMP Script   5.0   64.140949
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   AGM.dll   AGM 2010/12/13-23:37:10   64.449933   64.449933
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   Sponge 12.0
   Sprayed Strokes 12.0
   Stained Glass 12.0
   Stamp 12.0
   Sumi-e 12.0
   Targa 12.0.2
   Texturizer 12.0
   Tiles 12.0.2
   Torn Edges 12.0
   Twirl 12.0.2
   Underpainting 12.0
   Vanishing Point 12.0
   Variations 12.1 (12.1x20110328 [20110328.r.145 2011/03/28:10:30:00 cutoff; r branch])
   Water Paper 12.0
   Watercolor 12.0
   Wave 12.0.2
   WIA Support 12.1 (12.1x20110328 [20110328.r.145 2011/03/28:10:30:00 cutoff; r branch])
   Wind 12.0.2
   Wireless Bitmap 12.1 (12.1x20110328 [20110328.r.145 2011/03/28:10:30:00 cutoff; r branch])
   ZigZag 12.0.2
Plug-ins that failed to load: NONE
Flash:
   Mini Bridge
   Access CS Live
   Flash
   Kuler
   CS Review
Installed TWAIN devices: NONE

In my opinion, there's nothing wrong with your choice of Spot Healing Brush for this image. I cropped your screenshot to the "BEFORE" image, removed the "BEFORE" type (with the SHB) and scaled to 600% to match your original document.
A dab of a 0% hardness 500 pixel Spot Healing Brush in Ps CS5.1 on OS X 10.6.8 worked perfectly. However, I would have made a vertical stroke with the brush at about 80% hardness and about 200 pixels, which also works for me.
Maybe your SHB is working in "Create Texture" mode despite specifying "Proximity Match" in Options bar. Try resetting the SHB by right-clicking its icon at left of Options bar and picking "Reset Tool" from the menu that appears.

Photoshop CS5 - brushes, blur slow in higher resolution

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