Photoshop CS5: Can't drag or move anything with the mouse

I'm having a very strange issue with Photoshop CS5 (both 32-bit and 64-bit)
When I go to draw anything or move anything, the canvas does not respond to mouse events at all.  Right clicking doesn't work, dragging edges of the free transform box doesn't work, even the top menu bar (File, Edit, View, etc) does not detect when I mouse over from one menu selection to another (e.g. moving the mouse from "File" to "Edit")
Any ideas as to what might be causing this? just started yesterday night

I performed a System restore to a couple days ago and it seems to be working now.  Very odd behavior
EDIT: The problem started up immediately again.  Didn't do anything special, just continued scaling layers in photoshop and all of a sudden the mouse actions stopped having an effect on the canvas

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