Photoshop CS5 interface gets really slow only when an image is open

So this is really odd. Photoshop gets really slow when any image, regardless of size is open. When there are no images open it runs smoothly. The interface gets really laggy, filter usage, tool selection or any other usage is really sluggish, but only with an image open, even if it's a single pixel.
I've tried different performance settings - changing where the scatch drive is, how much memory to allocate, what the cache levels are set at, enabling/disabling openGL, etc. It makes no difference if it's after a fresh reboot or if it's been on for days. No software has changed since the upgrade. Memory test don't show any issues and no other application has this problem - Illustrator, After Effects, Maya, Mudbox, etc. are all fine.
My system specs
Windows 7 x64 Enterprise - Service pack 1 installed
Dual Xeon quadcore E5620 @ 2.4GHx (sixteen threads w/hyperthreading)
96 GB Ram - DDR3 - 1333 MHz / PC3-10600 - registered - ECC
Nvidia Quadro FX 3800 - with latest stable performance drivers v 295.73 (tried changing these, no affect)
Western Digital VelociRaptor 150GB 10000 RPM 16MB Cache SATA 3.0Gb/s OS Drive
X3 Seagate Constellation 2TB 7200 RPM SAS 6Gb/s setup in a RAID 5 config
I'd think it would be a memory issue if all apps had similar problems, or if PS had issues when just being open. It's odd that it happens only when an image is open.
Thanks for any an all help.
Duncan

Duncan York wrote:
I've tried different ..., enabling/disabling openGL,
Just to make sure, did you close and restart Photoshop after changing OpenGL settings and before testing? That's important, and not having done so could lead you to invalid assumptions.
-Noel

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Photoshop CS5 interface gets really slow only when an image is open