Photoshop (CS6 on Mac) file is locked.

After changing preferences, plug in views, etc I get a message the file is locked and changes won't be saved. Even after unlocking, adding myself as user with read/write priveleges, changes are not saved when PS is closed.
Help??

First thing to do is to trash your preferences while you re-launch Photoshop:
Preferences files vary by name and location for each version of Photoshop. Use this document to find or re-create preferences files for Photoshop CS6.
To re-create the preferences files for Photoshop, start the application while holding down Command+Option+Shift (Mac OS). Then, click Yes to the message, "Delete the Adobe Photoshop Settings file?"
Note: If this process doesn't work for you while you're using a wireless (Bluetooth) keyboard, attach a wired keyboard and retry.
Important: If you re-create the preferences by deleting the Adobe Photoshop CS6 Settings file, make sure that you only delete that file. If you delete the entire settings folder, you also delete any unsaved actions or presets.
Reinstalling Photoshop does not remove the preferences file. Before reinstalling Photoshop, re-create your preferences.
NEW Video! Julieanne Kost created a video that takes you through two ways of resetting your Photoshop preferences. The manual preference file removal method is between 0:00 - 5:05. The keyboard shortcut method is between 5:05 - 8:18. The video is located here.
Mac OS
Important: Apple made the user library folder hidden by default with the release of Mac OS X 10.7. If  you require access to files in the hidden library folder to perform Adobe-related troubleshooting, see How to access hidden user library files.
Then Repair Permissions with Apple's Disk Utility, and relaunch Photoshop.

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