Photoshop Does Not Open Lightroom Image

Every few weeks, when I open Lightroom, I cannot edit my images in Photoshop.  I'll select Photo->Edit in->Edit in Adobe Photoshop CS5.  Photoshop then opens.  Instead of displaying the image I'd just been working on in Lightroom, Photoshop brings up the standard file "Open" dialog.  (I've learned that if I then try to open the image using this dialog, the TIFF file is not properly exported back to Lightroom.)  To the best of my knowledge, this does not happen if I tell LR to open the image in Photoshop CS4.  The only work-around I've found is to optimize the Lightroom catalog, shut down both LR and PS, and restart my Mac.  Sometimes it takes several tries -- eventually it will start working again.  Once I get the LR-PS linking re-established, it will continue to work properly for the remainder of my work session.
Details: I'm running Lightroom 3.3 and PS 12.0.2 x64 on a Mac Pro.  My Lightroom catalog has around 11,000 images in it at the present time.
Any suggestions would be appreeciated!  Thanks, Steve.

Thanks for your suggestions.  I just found an earlier thread that suggested deleting both the Photoshop and Lightroom preference files.  I will try that.  I'll also try to update my version of PS.  (I have the CS5 updater running -- I'm surprised I don't have the latest version.)
If those things don't work, I'll try reinstalling.  One of the frustrations with these intermittent problems is that you're never quite sure if you've fixed it.  I'll give your suggestions a shot, and then I just have to watch for a while and see if LR and PS will work together,

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