Photoshop does not respond, once after startup!

Hi there,
Recently, i have bought a design standard CS 5.5, after installing and using for quite some time. The Photoshop CS 5.5 does not respond whenever i want to open any Photoshop file, once after startup?
This issues has only occur in Photoshop but not my other adobe products.
Hope to get some help!

Boilerplate-text:
Are Photoshop and OS fully updated and have you performed the usual trouble-shooting routines (trashing prefs by keeping ctrl-alt-shift pressed while starting Photoshop, 3rd party plug-ins deactivation, system maintenance etc.)?

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