Photoshop & general CS4 funkiness in XP that started a few months ago

This is a multi-part pain in the butt.
Part one: Sporadically, PShop CS4 decides it will not open a file. I can try and open it through the Open Dialog... No Luck. I can go and find the file in XP's file manager and choose "Open With" select Photoshop CS4... No Luck. I can even go into Bridge, find the file and ask Bridge to open the file in Photoshop, and you guessed it... No luck.
I have to physically reboot my computer and even then that solution isn't 100%. It's a pain, but something I've JUST been dealing with. It got on the other side of frustration today when I had two clients over my shoulder and couldn't open their files (or any other files for that matter). So we had to reschedule our meeting and HOPEFULLY I can get this resolved with your help.
The other issue, and this is CS4 wide, the key commands no longer work right. It's not just Photoshop, but all of the programs in CS4. If I choose CTRL + H to hide elements the layer I have active gets deleted. If I click on any tool, for example the Pick Tool I get the Hand tool. I then have to hit the SPACE BAR to activate the chosen tool.
Again, this is systemic [at least] across CS4 Ilustrator, InDesign, Photoshop (the main set of tools I use).
Please help. It's becoming a major buzzkill!
Thanks.
Mark

What version of XP?
64 bit? PS CS4 is not supported on XP 64 bit and has acted weird on a lot of systems in past postings.
32 bit? XP SP3, correct?
Since things are acting weird I would back up all your needed files.
First thing to do is, or what I do is, run the command sfc /scannow.exe in a elevated command prompt. This is a system file checker and it will verify system files are correct and not damaged.
Also try MicroSoft Fix it.
http://support.microsoft.com/fixit#tab0
Doing this will help rule out windows
Also look in Windows XP Event Manager to see if any hits are listed. Post the results here if you find any.

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