Photoshop won't open because scratch file is not available!

Hi, When I try to open my CS5 version of PS, it gives me this error: "Could not open a scratch file because the disk is not available" When I click OK, is gives another warning: "Could not initialize Photoshop because the disk is not available." I have tried uninstalling and reinstalling PS and I still get this problem. I can't open the program to see what is going on with the scratch file/disk! Does anyone know what I can do?
Thanks,
kt

Hi, It was Shift, Option and Command keys on a Mac. Thanks for the video link!
Thanks,
kt

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OK, here comes the explanation of what the scratch disk does and why it's optimal to have it on a physically separate internal drive (not partition!) other than your boot drive
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