PIAFUSER PIDIRUSER & PIISUSER are getting locked  , when cache is refreshed

Hi XI Gurus,
My scenario goes like this.. Sonic MQ <- XI <- SAP CRM.The messages sent from CRM are reaching XI but not are not making to Sonic, and the error message in SXMB_MONI of XI is <SAP:Category>XIServer</SAP:Category>
  <SAP:Code area="INTERNAL">HTTP_RESP_STATUS_CODE_NOT_OK</SAP:Code>
  <SAP:P1>401</SAP:P1>
  <SAP:P2>Unauthorized</SAP:P2>
I know this problem deals with the aunthentication.The users PIAFUSER PIDIRUSER & PIISUSER are getting locked when ever Iam trying to refresh cache in ID.When I unlock them and again refresh the cache they are again getting locked.when I unlock the users and restart the message it gives me an error of cache probelm .The mesage is stuck at call adapter phase in SXMB_MONI.Iam really confused of what to do.. please help me..

And when the locks are gone it gives me the following error
I have checked my receiver side every thing is fine.
<SAP:Category>XIAdapterFramework</SAP:Category>
  <SAP:Code area="MESSAGE">GENERAL</SAP:Code>
  <SAP:P1 />
  <SAP:P2 />
  <SAP:P3 />
  <SAP:P4 />
  <SAP:AdditionalText>com.sap.aii.af.ra.ms.api.ConfigException: ConfigException in XI protocol handler. Failed to determine a receiver agreement for the given message. Root cause: com.sap.aii.af.service.cpa.impl.exception.CPALookupException: Couldn't retrieve outbound binding for the given P/S/A values: FP=;TP=;FS=CRSCLNT100;TS=Sonic_BusService;AN=EMADispositionIN;ANS=urn:mentorg.com:ema:disposition;</SAP:AdditionalText>
  <SAP:ApplicationFaultMessage namespace="" />

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