Please help! Error -48 can't sync, tried everything!!

Hi
as above really, I have had my ipod 20gb clickwheel nearly 4 years and no problems, all of a sudden itunes has come up with this error message. I cannot take off or put songs onto the ipod, or move them around in playlists etc, but when not connected to my pc the ipod itself works fine.
Please help, I have tried most things such as unistalling itunes, error-checking the disk in my computer etc.
Has anyone got any other suggestions? I don't really want to restore the ipod as some of my music is not backed up, I manage it manually it that helps??

Use this microsoft installer cleanup tool to get reid of itunes, then quicktime.
http://support.microsoft.com/kb/290301
Then try a fresh iTunes install.

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