Premiere Pro CS6 Generates HUGE file - Encoder settings help please

Question

Using PPCS6 to create a 6 minute AVI file. The source video is an AVI screen capture from Camtasia for an application that is spread across 3 widescreen monitors, making the screen/video resolution 5760x1200 with a frame rate of 30. I need to output the same resolution/aspect ratio (Camtasia will not do this, hence my use of Premiere).
The initial screen capture is just under 2GB.
The AVI output from Media encoder is 45GB which is just too big to use.
Is there some settings I can use that will create a file of approximately the same size (under 3GB) and still look as sharp as the original capture?
My current encoder settings are:
Codec: Microsoft Video 1
Quality: 90
Width: 5760
Height: 1200
Frame Rate: 30
Field Order: Lower First
Aspect: Square Pixels (1.0)
Depth: 8-bit
Keyframe Interval: 8
Optimize Stills checked.

Answer 1

Camtasia files use their own TechSmith codec (TSCC) which is highly optimized for screen captures where hardly anything changes from frame to frame, and realistically you can't beat it with any of the default codecs, which are designed for full-motion video. With MV1 that file size is about what I'd expect from such a massive resolution. Also, do you really need 30fps? Most screencaps will look OK at 15 or even 12 at a push.
You should be able to encode back to AVI/TSCC if you have Camtasia on the same machine as Prem, if not you can download the codec pack for free from Techsmith's website.