Preview opens but toolbar is unresponsive

Have an issue with preview. I am able to open images with preview but the toolbar is completely unresponsive, i have no control of the functions such as zoom. I am even unable to close using the red button, I have to either force quit or for some reason right click and quit at the lower icon. The main tool bar at the top of the screen also will not respond when preview is selected, unless I use right click (very wierd). Is there anyone else out there having this problem.
Using Lion and have tried repairing disk permissions to no avail.

Justin, I seem to be going down the same path:
I am experiencing this strange strange phenomenon with the Preview application and Mac OS X Lion on my MacBook Pro 13": When I launch a file within Preview, it opens normally and I can scroll, zoom and view its contents. However, everything I need a left mouse click for, I can not access. Right clicking within a window works, i.e. I get the context menu. The left click problem is also present for resizing the window or clicking on the upper right icon for full screen mode. Everything is visible, nothing is "clickable".
Outside of the preview app, everything works normally, so I do not have an issue with the trackpad/mouse
So far, I tried the following:
- I replaced the preview app from another Lion installation
- I confirmed that the same behavior happens with an external mouse
- I deleted all the property files related to Preview (com.apple.Preview*) in my Library/Preferences folder.
- I repaired permissions
All this had no effect.
With a different user account on the same machine, everything is in order. So this must be caused by some configuration problem within my user context.
I have run out of ideas… any tips are welcome.
-Jens

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Thanks for your lengthy reminder dude, I have a similar Mac with yours. I suspect its a software fault because it happens after I upgraded to Lion, 10.7.2.

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Well, everything was running (nearly), but since this morning when I want to view an image or a pdf, preview opens but does not show me the pdf or picture.
Iv' tried opening preview and than do file-open file, but I just got the same result.
any clues.
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Log back into your problem account:
Here's the whole litany for thoroughly checking your home folder. It's not as daunting as it looks.
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• Restart and test your applications.
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( Likely suspects are Times RO, Helvetica Fractions and Times Phonetic, also if you do not use Classic you can trash the classic fonts.) If not, replace your Fonts folder.
2. Check Preferences Thoroughly;
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• Restart and test your applications.
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** Note: A very important file is the "com.apple.Mail.plist" preference file located in the Preferences folder which contains all email account settings and general mail preferences (hold this one and replace if your problem is not with Mail).
You'll have to go through some of your System Preferences and apps to set the preferences back to how you like them. (Or if you have the time and inclination, "cherry pick" through until you find the problem one or two.)
3. Check Permissions Inside Home Folder
• Navigate to YourHome/Library.
• Get Info (Command - i) on folders for apps you are having problems with.
• Open the "Ownership & permissions" disclosure triangle.
• Make sure you are the owner, with "read and write" access.
• Click on "apply to all"
• If this is correct, open the "Applications Support" folder and do the same procedure (Command+I) for the folders with the names of the applications you are having trouble with.
(Note:The reason to check this is because repairing permissions with Disk Utility doesn't touch permissions inside your home folder.)
4. Navigate to YourHome/Library/Caches and drag this folder to the trash, then log out and back or restart. There is no need to replace this folder.
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Preview opens but toolbar is unresponsive

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