Preview won't open... again! Please help!

A few months agom Preview stopped working out of the blue and I was very grateful to find a solution on this Forum (originally posted by Fred Robinson). This was to delete a com.apple file in Library and Preferences.
Now, the same seems to be happening. If I double click a jpg on my desktop, the 'Triv' timer starts up, then nothing. Preview seems to be open in my Dock but nothing responds.
Obviously I can't delete the com.apple file again, because it's no longer there. Does anyone have any ideas?
iBook G4   Mac OS X (10.3.9)   1.2GHz PowerPC G4, 768 DDR SDRAM

Thanks very much for the advice.
I'm glad to say that you were right.
Interestingly, I could not SEE the Preview plist file in there when I looked, but when I did a 'find', there it was. Strange eh?
Once deleted, the problem was solved.
Thanks again
Matt

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