Preview won't open.....period

I have seen other topics on Preview, however it seems they are all about opening multiple files. I am unable to open preview at all. I deleted the com.apple.preview plist file and still doesn't work.
When I try to open a pdf, Preview just blinks and blinks trying to to open. After a about 15 seconds or so, it stops blinking but does not respond. The Preview menu doesn't appear at the top of screen either.
This all seemed to happen after I upgraded to SL. Preview was fine in prior versions.
Any help would be great!
Thanks

Welcome to Apple Discussions.
Create a new User go to System Preferences >> Accounts >> "+" (make it an admin acct) and test the Preview in this new account, if it works the problem is isolated to your User and not systemwide.
-mj

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