Problem Installing iPhone 2.0 (Error -5000)

When I try to install iPhone 2.0 through iTunes, I am getting this message during backup of the iPhone:
An error occurred while backing up this iPhone (-5000). Would you like to continue to update this iPhone without backup?
Continuing without backup will result in in the loss of all contents on this iPhone.
Any ideas on how to fix this?
Thanks

Deattach all your USB items
Don't use the iPhone dock
http://discussions.apple.com/thread.jspa?threadID=1599349&tstart=0

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