Problem Loading Lightroom

Hello everyone,
Recently my installation of lightroom has stopped loading giving this error message:
Adobe Photoshop Lightroom 5 cannot be opened because of a problem.
Check with the developer to make sure Adobe Photoshop Lightroom 5 works with this version of Mac OS X. You may need to reinstall the application. Be sure to install any available updates for the application and Mac OS X.
I have uninstalled and reinstalled multiple times with various different versions of lightroom. I have cleared the preferences and various other things in the library files, I have run all the various OS X cleaning tools, mended file permission etc.
The frustrating thing is that it used to work fine! I can't pin point a particular change that happened before it stopped working.
I have a MacMini 1.83 GHz Core 2 Duo, 3GB Ram OS X 10.7.5.
Any suggestions would be much appreciated.
Thank you.

Although I used a Mac and OS X for several years I gave up on it for just these type of things happening out of the blue. No rhyme or reason for them.
The only option I found to cure some of the glitches with OS X was to wipe the drive and start over with a fresh install of the OS and programs and or restoring the system from a known Good backup made with either Time Machine or one of the Disk Cloning apps available for OS X.
You could try using Disk Utility to do a repair of permissions that is found on the First Aid tab. That sometimes fixed issues like this.
It seems OS X sometimes forgets disk/file permissions and lock them as system, read only or restricted files stopping apps from opening or you saving files to a specific location.

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