Problem opening downloaded i tunes

RECENTLY CARRIED OUT A REGISTRY CLEAN POSSIBLY MAY HAVE AFFECTED DRIVER APPL TO I TUNES SEQUENCE AS FOLLOWS..
On clicking on itunes icon ."itunes" heading Microsoft will have to close due to the following problem....
C:\DOCUM~1\Robert\Locals~\Temp\b51d_appcompat.txt
I then attempted to go back via "System restore" to a time prior to registry clean
On attempting prior date message comes up....
"CHANGES MADE TO DRIVE(S) E AFTER THIS POINT CANNOT BE REVERSED BECAUSE THE DRIVE WAS EITHER EXCLUDED FROM SYSTEM RESTORE MONITORING OR WAS TURNED OFF OR REMOVED
Any suggsetions appreciated

let's first check to see if this is associated with a problem with your QuickTime. (iTunes needs a properly functioning QuickTime in order to work correctly.)
try launching your QuickTime. does it:
(a) launch perfectly fine?
(b) fail to launch with an error message? (if so, what does it say?)
(c) exhibit other peculiar behavior? (if so, could you describe it for us?)

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I have previously asked for help with this problem and received several suggestions that did not work. I now have more information that may provide a clue. I have the same version (34.0.5) on my win8 pc and it works fine. Also I recently restored mty win7 pc to factory configuration (new pc status).

''ram085 [[#question-1037011|said]]''
<blockquote>
I have previously asked for help with this problem and received several suggestions that did not work. I now have more information that may provide a clue. I have the same version (34.0.5) on my win8 pc and it works fine. Also I recently restored mty win7 pc to factory configuration (new pc status).
</blockquote>

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Try this...
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http://support.apple.com/kb/HT1414
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Problem opening downloaded i tunes

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