Problem Saving Files CS5

After years of no problems I am suddenly having a problem saving files.  This started with CS4 a few months ago, and has continued with CS5.
When I attempt to Save As... I get an error message:
     Could not save as "{location & filename}" because the file is already in use or was left open by another application.
The only place the file could be considered "in use" or "left open" would be due to Bridge.
I get this error message whether saving as jpg, psd or any other file type.  If I retry saving the file then it will usually save properly after several attempts.  But if I close Bridge then it will save the first time every time.  I get the same error whether saving as the original file name or with a new name.
I have been using Bridge to preview and select the images I want to edit for a very long time.  But this problem didn't start showing up until a short time ago, so I wonder about a problem introduced with an update??    Those who use Bridge know that it remains running in the background while the image is processed through Camera RAW and PS.  There has never been a reason to close Bridge when working in PS and it is not very convenient to do so just to save a file.
If anyone has a solution to this I would like to hear about it.
Thanks,

Hi Jimcarke,
My problem is very similar. Just Upgraded to CS5 from CS4.
Graphic files, no problem.  I can save 80Mb and 30 layered mixed graphic files, even after editing.
No JPEG's in the stack though. Perhaps I'll have a look at that!
With simple JPEG's at 1.9mb, after editing, then as soon as I enter 'Save As,' Bingo the great blank screen'
Problem seems worse if I get as far as rotating the image, then everything disappears instantly.
Customer services have suggested all the usual remedies and now I can't open a file or edit anything
I'm back to the insufficient RAM issue.
I've just 'given up' and back to CS4 again and will try to get some work done for the morning.
All good fun and an interesting way to spend a very sunny Sunday afternoon. (GB)
Regards
John

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