Problem with Adobe Acrobat/Reader when opening a Link in Safari???

For some reason when I'm on a web page that has a link to a PDF file, Safari opens a new window and I get a popup error.  See attached screen shot.
Acrobat is not running.  I've tried quitting and re-starting Safari (5.1.7) and even restarting Mac OSX (Snow Leopard 10.6.8).
Any ideas???

How? I'm having the same problem.

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