Problems opening applications from Desktop

Hi,
When I click any icon from the desktop, nothing opens. But when I click icons on the dock, applications open. For example, when I click on the Macintosh HD icon on the desktop, it doesn't open
HELP!!!!

Ephraim, the time between your two posts was only 11 minutes! You have to be a little more patient than that, don't you think?
First, a really dumb question: your are +double clicking+ on the Desktop Folders, right? (I just can't take this for granted, sorry for asking.)
Try trashing this file: in your users (your account) /Library/Preferences/com.apple.desktop.Plist. A new one will be created automatically, but you will probably need to reestablish your Desktop Preferences.
Also try resetting the PRAM. At the chime, hold down Option-CMD-P-R until you hear two more chimes (total 3) then let go and it will continue booting.
Sometimes a simple restart can fix things like this.

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