Problems saving open files

I've recently been having troubles saving an open PDF file. I'm getting the error message: "The document could not be saved. The file may be read-only, or another user may have it opened. Please save the document with a different name or in a different folder." This happens randomly and happens on more than just particular one file. Currently I'm running Acrobat Professional 9.4.1 on a Windows 7 Ultimate operating system.  Any ideas on how to resolve this?

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