Problems sending ISP mail on mac

I wonder if anyone can help me with a Mail issue.  I'm using my own domain's email address in Mail,and am experiencing an unusual problem.  I'm able to both send and receive email, but should I send an email, and then receive a reply, I can't send a further reply unless I shut down Mail, and then reopen it.  It then sends just fine.  The error message I receive says "Cannot send message using the server mail.xxxxxx.co.uk"  It then suggests I verify the server settings, but I know these are correct as I've double and triple checked them, and contacted the support guys from my hosting service, who have confirmed they are set correctly.
What happens is I always have to select "Try Later" in the error message, close down Mail, reopen it, at which point the same error message pops up, only this time I select "Try with selected server", which is the same one that earlier refused to send it, and it sends without a problem.  I can then send as many emails as I like, but as soon as I receive a reply from someone, I have to go through the whole process again.  I don't have this problem with my mac.com emails, they send just fine.
Any ideas?  I'm at a loss, and I really don't want to switch to another email client, as I like Mail.

i am having similar issues.
Is the problem on APPLE side or our side. I cannot send any mail.

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