Problems with CS4 Locking up after File I/O

I am running:
Vista Ultimate Service Pack 2
Photoshop CS4 with the opengl off
Problem: When I either create a new file or open an already established file the program becomes unresponsive. It locks and hangs. I have read through and tried the KB article that I was giving by support. I have not been able to figure out what is going on. As far as I can tell all of the services that should be running are. Is this a permissions issue with the OS? Just don't know. Please help if you can.
Thanks,

You can right click on the .exe file and choose properties, then compatibility, and select run as administrator.
Also try the ole fix all reset the prefs in this attachment:
http://forums.adobe.com/thread/375776?tstart=0

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