.profile can't be edited and saved in pico

there's no content in the .profile file if I type "pico ˜/.profile" in the terminal, and I can't edit and save changes to it via pico.
The error message in pico is "Error writing ˜/.profile: No such file or directory". But this file actually exists and has contents in it.
I can only edit and save .profile using Sublime Text editor. And this can be performed on another iMac of mine.
May I ask why?
Thanks!

pico .profile
or
pico ~/.profile

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.profile can't be edited and saved in pico

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