Program running slowly

I'm running an iMac with maximized RAM and the latest OS. Past couple of days, Lightroom 4 has been running slowly. The interface with the Nik software plugins especially. I optimized the system with CleanMyMac software and optimized the disk permissions. I keep my photo files on an external Drobo system, which has been optimized. Anybody have any clues?
thanks
Renzo

http://forums.adobe.com/thread/971581
http://forums.adobe.com/thread/1016927
Rather than have another "Lr 4 is slow" thread, can I suggest you spend some time checking out the many suggestions in these existing discussions, Renzo?

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